NAD⁺ (nicotinamide adenine dinucleotide) is a coenzyme widely discussed in laboratory and preclinical research due to its role in cellular energy metabolism and redox signaling. It has become a key focus in research models examining cellular function and metabolic processes.
This page provides an educational overview of NAD⁺ for laboratory research purposes only. NexPept supplies NAD⁺ strictly for non-clinical research applications, with an emphasis on purity, documentation, and consistency. New to the topic? Start with our guide to what research peptides are or our overview of research peptides in Canada.
NAD⁺ is intended strictly for laboratory research use only. It has not been authorized by Health Canada for human or veterinary use.
What Is NAD⁺?
NAD⁺ is a naturally occurring dinucleotide coenzyme found in all living cells, functioning as an essential redox cofactor in cellular energy metabolism. In research environments, it is studied for its role as an electron carrier in key metabolic pathways and as a substrate for enzymes including sirtuins and poly(ADP-ribose) polymerases (PARPs).
Due to its central role in cellular processes, NAD⁺ has become one of the most frequently referenced compounds in laboratory research involving energy regulation and cellular signaling pathways.
NAD⁺ Chemical Profile: CAS Number, Formula & Molecular Weight
The core identifiers for NAD⁺ are listed below. Researchers use these values to confirm that the material they receive matches the compound they ordered.
| Compound | NAD⁺ (oxidized form) |
| Full name | Nicotinamide Adenine Dinucleotide |
| CAS number | 53-84-9 |
| Classification | Dinucleotide coenzyme, redox cofactor |
| Molecular formula | C21H27N7O14P2 |
| Molecular weight | 663.43 g/mol |
| Enzyme substrates | Sirtuins (SIRT1–7), PARPs, CD38, NMNAT |
| Physical form | Lyophilized powder, white to off-white solid |
| Analytical methods | HPLC + mass spectrometry (MS) |
Why Researchers Study NAD⁺
In preclinical and laboratory research settings, NAD⁺ has been investigated for its potential involvement in:
All findings related to NAD⁺ remain within research and experimental contexts, and interpretations should be confined strictly to laboratory data. To explore the published literature, you can search PubMed for NAD+ research papers.
NAD⁺ Purity & Certificate of Analysis
High purity and proper documentation are essential for reliable and reproducible research outcomes. Inconsistent quality or incomplete analytical data can compromise experimental results. High-quality research compounds should include third-party analytical testing, batch-specific identification, verified purity percentages, and a transparent certificate of analysis (COA).
The current NexPept NAD⁺ 500mg batch reports the following:
Storage & Handling (Research Use)
Proper storage and handling help preserve compound stability during laboratory research. NAD⁺ is hygroscopic and sensitive to moisture and light. General laboratory considerations may include:
Always follow your laboratory's established procedures when working with research compounds. No preparation, reconstitution, or administration instructions are provided.
NAD⁺ Research Product
Researchers seeking NAD⁺ for laboratory use can view the corresponding product page below:
NAD⁺ Research FAQ
What is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a naturally occurring dinucleotide coenzyme found in all living cells. It functions as an essential redox cofactor in cellular energy metabolism, and NexPept supplies it as a lyophilized powder for laboratory research use.
What is the CAS number for NAD+?
The CAS registry number for NAD+ (oxidized form) is 53-84-9.
What is the molecular weight and formula of NAD+?
NAD+ has the molecular formula C21H27N7O14P2 and a molecular weight of approximately 663.43 g/mol.
What enzymes use NAD+ as a substrate?
In research contexts, NAD+ is studied as a substrate for sirtuins (SIRT1–7), poly(ADP-ribose) polymerases (PARPs), CD38, and NMNAT, among other NAD+-dependent enzymes.
Is NAD+ approved by Health Canada?
No. NAD+ has not been authorized by Health Canada for human or veterinary use. NexPept supplies it strictly for in vitro laboratory research.
How should NAD+ be stored for research?
Store sealed lyophilized material under controlled laboratory conditions, protected from light and moisture, since NAD+ is hygroscopic. Follow your institution's approved handling protocols.