5-Amino-1MQ: The NNMT Inhibitor Researchers Are Talking About
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a synthetic research compound studied for its ability to block a specific enzyme linked to cellular energy and metabolism. Available in Canada from NexPept — HPLC and MS verified, shipped from Ontario.
What Is 5-Amino-1MQ?
5-Amino-1MQ — short for 5-Amino-1-methylquinolinium iodide — is a small synthetic molecule that scientists use in laboratory research. Its job is to block (or "inhibit") an enzyme in cells called NNMT (Nicotinamide N-methyltransferase). Think of NNMT as a dial inside cells that controls how much energy the cell can make and use. When NNMT is too active, it can drain the cell's energy supply. 5-Amino-1MQ is researched as a tool to study what happens when you turn that dial down.
It was first described in published scientific literature as a potent, selective NNMT inhibitor with an IC₅₀ of approximately 1.2 μM — a measure of how little of the compound is needed to have a measurable effect in lab tests. NexPept supplies 5-Amino-1MQ as a research-grade powder for qualified Canadian laboratories and research institutions — see what research compounds are for how research-grade material differs from a drug or supplement.
How Does 5-Amino-1MQ Work? (Simple Version)
Cells run on energy, and a molecule called NAD⁺ is the fuel. NNMT is an enzyme that "uses up" ingredients cells need to make NAD⁺. When researchers block NNMT with 5-Amino-1MQ in cell studies, they can observe whether the cell's NAD⁺ levels change — and what else changes with them. Here's how researchers describe the chain of events:
NNMT Is Blocked
5-Amino-1MQ binds to the NNMT enzyme inside the cell, slowing it down. In lab tests, this happens at very low concentrations (IC₅₀ ≈ 1.2 μM).
NAD⁺ Precursors Are Freed Up
With NNMT slowed, more of the building blocks (like Nam — nicotinamide) are available to be recycled into NAD⁺ through the cell's salvage pathway.
Researchers Observe Results
Scientists measure how changes in NAD⁺ levels and related pathways affect cell behaviour in their in vitro (test tube / cell culture) experiments.
NAD⁺ (Nicotinamide Adenine Dinucleotide) is one of the most studied molecules in cell biology. It plays a central role in how cells produce energy, repair DNA, and regulate metabolic processes. Research interest in compounds that influence NAD⁺ levels — like NNMT inhibitors — has grown significantly over the past decade. Our NAD+ research overview covers the coenzyme itself in more depth.
5-Amino-1MQ gives researchers a precise, selective tool to study the NNMT enzyme's role in this system — without the broad, non-specific effects that some older research compounds produce.
What Are Scientists Studying With 5-Amino-1MQ?
Published in vitro and preclinical research has explored 5-Amino-1MQ across several areas of cell biology. The compound is valued for its selectivity — it targets NNMT specifically, making it a cleaner tool for experiments that need to isolate the enzyme's effects.
Cellular Energy Metabolism
Researchers use 5-Amino-1MQ to study how NNMT activity affects NAD⁺ levels and mitochondrial function in cultured cell models — helping map how cells produce and regulate energy. Related work often runs alongside MOTS-c and SS-31, which approach mitochondrial function from different angles.
Adipocyte (Fat Cell) Studies
NNMT is known to be highly expressed in fat tissue. In vitro studies have used 5-Amino-1MQ to investigate what happens to fat cell metabolism when the enzyme is inhibited under controlled laboratory conditions.
SAM / Methyl Group Transfer
NNMT consumes SAM (S-adenosylmethionine), a molecule cells use to add "methyl groups" to many targets. Blocking NNMT with 5-Amino-1MQ lets researchers study how SAM availability changes gene expression and cellular signalling.
5-Amino-1MQ Research Fast Facts
(in vitro)
(g/mol)
Formula
Method
Common Questions About 5-Amino-1MQ
What exactly is NNMT and why do researchers study it?
How is 5-Amino-1MQ different from NAD⁺ precursors like NMN or NR?
What form does NexPept's 5-Amino-1MQ come in?
Can I buy 5-Amino-1MQ in Canada?
Is there published peer-reviewed research on 5-Amino-1MQ?
Compounds and Guides Researchers Pair With This
5-Amino-1MQ sits at the intersection of NAD⁺ metabolism and methyl-group transfer, so it is frequently studied alongside compounds addressing adjacent parts of the same system.
NAD+ Research Overview
The coenzyme at the centre of this pathway — redox chemistry, research applications and handling.
MOTS-c Overview
Mitochondrial-derived peptide studied in metabolic and AMPK-related signalling research.
SS-31 Peptide Guide
Cardiolipin binding and inner-mitochondrial-membrane function, explained from the literature.
Further reading: metabolic research peptides in Canada · research peptides in Canada guide · what to check before ordering · COA library · browse metabolic research · FAQ · verify the official site
5-Amino-1MQ is manufactured and supplied by NexPept for in vitro laboratory research purposes only. This compound is not approved for human or veterinary use, is not a drug or supplement, and is not intended for diagnosis, treatment, prevention, or cure of any condition. All information on this page describes preclinical and in vitro research findings — not clinical outcomes. Researchers are responsible for ensuring compliance with all applicable Canadian federal and provincial regulations governing the acquisition and use of research compounds. This product should be handled only by qualified research personnel in an appropriate laboratory setting.
Buy 5-Amino-1MQ in Canada — HPLC & MS Verified
Shipped from Ontario via Canada Post Xpress Post · Batch COA published in our library · Same-day dispatch before 2 PM EST